Marmaduke, the world's most lovable Great Dane, leaps from comic strip fame (appearing in 600 newspapers in over 20 countries) to big screen stardom. In this family comedy event, the super-sized, ultra-awkward lap dog is living the good life with the Winslow family, including beleaguered dad Phil, Phil's wife Debbie, their three children, and feline pal Carlos. But when Phil uproots the clan from Kansas to California, Marmaduke finds his life turned upside-down. He must navigate the volatile Mutts vs. Pedigrees turf wars, woo the purebred of his dreams, and overcome a fall from grace from his new four-legged friends and his much put-upon family.